“A couple from Kingston adopted the twin girls from Vietnam when they were 18 months old. Both have Alagille syndrome, a disorder that affects internal organs. The girls’ father, Michael, was a genetic match — but he could only donate part of his liver to one of his then-three-year-old daughters. Doctors decided which of the twins would receive the liver transplant from their father after the family said it could not make the heart-wrenching decision.” https://www.cbc.ca/news/canada/toronto/anonymous-donor-kingston-1.3728111
The diagnosis and treatment of a life-threatening illness could of course be considered significant. The ethical issues in this RLE may be even more significant though.